Table 5 GO assignments of biological processes and molecular functions for examples of individual eigenclusters with FunSpec.[82] The number of proteins with the same GO annotation is in parenthesis, and the numbers in square brackets are the p-values for the assignments.
From: Functional clustering of yeast proteins from the protein-protein interaction network
Eigenvector | Number of significant proteins | GO Biological Process | GO Molecular Function |
|---|---|---|---|
106 | 17 | DNA metabolism (10) [3 × 10-8], chromosome organization and biogenesis (7) [1 × 10-7], nuclear organization and biogenesis (7) [4 × 10-7], M phase (7) [3 × 10-6], cell organization and biogenesis (11) [4 × 10-6] | Double-stranded DNA binding (2) [2 × 10-4], single-stranded DNA binding (2) [4 × 10-4], DNA helicase (2) [1 × 10- 3], DNA binding (5) [3 × 10-3], Binding (8) [5 × 10-3] |
267 | 55 | Cell growth and maintenance (50) [9 × 10-8], RNA metabolism (14) [2 × 10-7], RNA processing (13) [5 × 10-7], microtubule-based process (8) [8 × 10-7], mRNA processing (9) [9 × 10-7], nucleobase, nucleoside, nucleotide, and nucleic acid metabolism (24) [2 × 10-6] | Binding (28) [1 × 10-8], nucleic acid binding (21) [2 × 10-7], RNA binding (13) [2 × 10-7], mRNA binding (6) [5 × 10-5] |
304 | 51 | Nucleobase, nucleoside, nucleotide, and nucleic acid metabolism (36) [1 × 10-14], RNA processing (19) [1 × 10-13], mRNA processing (14) [4 × 10-13], RNA metabolism (19) [1 × 10-12], RNA splicing (12) [6 × 10-11], mRNA splicing (11) [1 × 10-10], metabolism (44) [2 × 10-10], cell growth and/or maintenance (49) [7 × 10-10] | Binding (32) [8 × 10-13], nucleic acid binding (25) [2 × 10- 11], RNA binding (14) [7 × 10-9], mRNA binding (6) [4 × 10-5] |