Skip to main content
Figure 1 | BMC Bioinformatics

Figure 1

From: Prediction of a key role of motifs binding E2F and NR2F in down-regulation of numerous genes during the development of the mouse hippocampus

Figure 1

Identification of motifs associated with the sign of Mode 2 during hippocampal development and/or neuronal differentiation. The ten most promising motifs associated with the sign of Mode 2 selected on the neuronal dataset were tested on the hippocampal dataset. The same procedure was repeated for the reverse choice of the training and the test dataset (hippocampal dataset used for training, neuronal for testing). A. Illustration of the training-test procedure. The X and Y coordinates represent single-test p-values computed for each feature on the neuronal and on the hippocampal dataset, shown as -log10(p-value). The 10 highest-ranking features on the neuronal dataset are indicated by blue dots, and the 10 highest-ranking features on the hippocampal dataset are indicated by red dots. The vertical (blue) line, and the horizontal (red) line mark the alpha thresholds of the corrected p-value 0.01 in the cross-system test, on the neuronal and the hippocampal dataset, respectively. The feature is significant in the cross-system test if a blue dot is above the red line, or a red dot is to the left of the blue line. The dots representing the significant features are labeled with motif names. A double coloring of a dot (blue on red) indicates a feature that was among the 10 highest ranking features on both the training and the test dataset – such features are also labeled. A dummy p-value of 2 was used to mark features absent in either dataset. B. Results of the training on the neuronal dataset and the test on the hippocampal dataset. "Feature name" corresponds to the Genomatix "matrix family name". "Down" and "Up" indicate the numbers of CNSs assigned to the genes with the negative and the positive sign of Mode 2. C. Results of the training on the hippocampal dataset and the test on the neuronal dataset.

Back to article page