Computational reconstitution. Schematic view of the gene expression in the synovial tissue (left) and the computationally reconstituted tissue profile (right). The expression of the synovial tissue is composed of the expression of macrophages , fibroblasts , and non-adherent cells . The expression of the whole tissue is measured as the overall expression profile S. The computationally reconstituted tissue profile S* is composed of the measured expression profiles of the isolated cell fractions, i.e. of macrophages M, fibroblasts F, and non-adherent cells N. The relative mRNA proportions p
, and p
are determined by matching the computationally reconstituted profile S* with the measured tissue profile S, The measured expression profiles are enframed using solid lines.