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Table 1 The multi-functions of genes defy a straightforward estimation of the mutual information. Each gene is assigned to a vector of binary attributes A = {A1, A2, ..., A N A MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGbbqqdaWgaaWcbaGaemOta40aaSbaaWqaaiabdgeabbqabaaaleqaaaaa@304B@ }, described by a number a i [0, 2 N A MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqaIYaGmdaahaaWcbeqaaiabd6eaonaaBaaameaacqWGbbqqaeqaaaaaaaa@3028@ - 1]. The contingency table to evaluate the mutual information I(C, [A1, ..., A N A MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGbbqqdaWgaaWcbaGaemOta40aaSbaaWqaaiabdgeabbqabaaaleqaaaaa@304B@ ]), taking all possible combinations into account, would thus include up to 2 N A MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqaIYaGmdaahaaWcbeqaaiabd6eaonaaBaaameaacqWGbbqqaeqaaaaaaaa@3028@ columns.

From: Validation and functional annotation of expression-based clusters based on gene ontology

   annotation  
  Cluster A 1 A 2 A 3 A 4 ... A N A MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGbbqqdaWgaaWcbaGaemOta40aaSbaaWqaaiabdgeabbqabaaaleqaaaaa@304B@ A
gene 1 1 0 1 0 0 ... 1 a 1
gene 2 2 0 0 0 1 ... 0 a 2
gene 3 1 1 0 1 0 ... 0 a 3
    ...