Figure 1

Accuracy of functional site identification by the entropy method, the default relative entropy method and the family-specific relative entropy method on the Thornton and Lovell datasets. The average ROC score and the top 10 hits score are used to evaluate performance. The family-specific relative entropy method has negligible difference in performance compared to the default relative entropy method using general background frequencies. Both relative entropy methods perform better than the entropy method, demonstrating that the incorporation of background frequency information improves functional site identification.