Figure 2

Example comparison of relative entropy and entropy methods. The structure of the example protein, an oxidoreductase (PDB identifier 1a65A), is shown in ribbon representation with the functional active sites (His-Cys-His) represented as spheres. For each method evaluated, each residue in the structure is colored by its predicted functional importance score, with the color changing from red to white to blue as the score decreases. The entropy method incorrectly assigns the highest scores to residues in the C-terminal region, but the two relative entropy methods correctly assign the highest scores to the active sites.