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Table 3 45 genes up-regulated in tumoral tissue, comparing normal mucosa to matched tumor colon tissue.

From: On the statistical assessment of classifiers using DNA microarray data

Function Gene OMIM Accession no. p-value Gene description
Cell cycle: mitosis (spindle checkpoint) TTK 604092 NM_003318.1 0.029 Threonine-tyrosine kinase
  BUB1 602452 AF043294.2 0.035 Budding uninhibited by benzimidazoles 1 homolog (yeast)
  BUB3 603719 NM_004725.1 0.037 Budding uninhibited by benzimidazoles 3 homolog (yeast)
  CDC20 603618 NM_001255.1 0.044 Cell division cycle 20
  MAD2L1 602686 NM_002358.2 0.049 MAD2 (mitotic arrest deficient, yeast, homolog) like-1
  BUB1B 602860 NM_001211.2 0.050 Budding uninhibited by benzimidazoles 1 homolog beta (yeast)
Cell cycle: G0/G1 transition INSIG1 602055 NM_005542.1 0.039 Insulin induced gene 1 (cell division cycle, G0 to G1)
Cell cycle: mitosis (G1/S checkpoint) CKS2 116901 NM_001827.1 0.047 CDC28 protein kinase regulatory subunit 2
  CKS1B 116900 NM_001826.1 0.046 CDC28 protein kinase regulatory subunit 1B
  SKP2 601436 BG105365 0.050 S-phase kinase-associated protein 2 (p45)
  FOXM1 602341 NM_021953.1 0.045 Forkhead box M1
  MCM4 602638 AA 604621 0.036 Minichromosome maintenance deficient (S. cerevisiae) 4
  MCM3 602693 NM_002388.2 0.048 Minichromosome maintenance deficient (S. cerevisiae) 3
  MCM7 600592 D55716.1 0.048 Minichromosome maintenance deficient 7 (S. cerevisiae)
  MCM2 116945 NM_004526.1 0.049 Minichromosome maintenance deficient (S. cerevisiae) 2
  MCM6 601806 NM_005915.2 0.050 Minichromosome maintenance deficient (S. pombe) 6
Cell cycle: mitosis (G1/S and G2/M checkpoints) CRKRS   M68520.1 0.039 Cdc2-related kinase, arginine/serine-rich
  CDC2/CDK1 116940 NM_001786.1 0.044 Cell division cycle 2, G1 to S and G2 to M
  CDC25A 116947 NM_001789.1 0.050 Cell division cycle 25A
  CDC25B 116949 NM_021873.1 0.050 Cell division cycle 25B
  CCNA2 123835 NM_001237.1 0.050 Cyclin A2
Cell cycle: mitosis (G2/M checkpoint) CCNB1 123836 Hs.23960 0.047 Cyclin B1(cell division cycle, G2 to M)
  CCNB2 602755 NM_004701.2 0.047 Cyclin B2 (cell division cycle, G2 to M)
  NEK2 604043 NM_002497.1 0.037 NIMA (never in mitosis gene a)-related kinase 2
Cell cycle: mitosis STK15 602687 NM_003600.1 0.039 Serine/threonine kinase 6 (chr segregation)
  SRPK1 601939 NM_003137.1 0.046 SFRS protein kinase 1 (chr segregation)
  TOP2A 126430 NM_001067.1 0.050 Topoisomerase (DNA) II alpha (170 kD) (chr segregation)
  KIF4A 300521 NM_012310.2 0.035 Kinesin family member 4A (spindle formation/chr condensation)
  CNAP1 609689 NM.014865 0.046 Chromosome condensation-related SMC-associated protein 1
  SMC4L1   NM_005496.1 0.048 SMC4 structural maintenance of chromosomes 4-like 1 (yeast)
  HCAP-G 606280 NM_022346.1 0.042 Chromosome condensation protein G (chr condensation)
Signal transduction TDGF1 187395 NM_003212.1 0.048 Teratocarcinoma-derived growth factor 1 (EGF signaling)
  ENC1 605173 NM_003633.1 0.048 Pig 10, ectodermal-neural cortex (WNT//beta-catenin pathway)
Transcription SOX9 608160 NM_000346.1 0.045 Sex determining region Y-box 9
  MYC 190080 NM_002467.1 0.047 V-myc avian myelocytomatosis viral oncogene homolog
  HGFR/MET 164860 NM_002467.1 0.047 Met proto-oncogene
Transport: intracellular NUP62 605815 NM_012346.1 0.039 Nucleoporin 62 kD
  NUPL1 607615 NM_007342.1 0.050 Nucleoporin-like 1
  NUP155 606694 NM_004298.1 0.045 Nucleoporin 155 kD (NUP155)
  KPNA2 600685 NM_002266.1 0.045 Karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
  RANBP5 602008 NM_002271.1 0.050 RAN binding protein 5 or karyopherin (importin) beta 3
  CSE1L/CAS 601342 NM_001316 0.050 CSE1 chromosome segregation 1-like (yeast)
  NXT1 605811 NM_005796.1 0.050 Nuclear transport factor 2 (NTF2)
  RANBP1 601180 NM_002882.2 0.048 RAN binding protein 1
Transport SLCO4A1 605495 NM_016354.1 0.048 Solute carrier family 21 (organic anion transporter)