Table 8 Candidate fragile genes in tumours.

Notes

References

GLMN

glomulin, FKBP associated protein

FRA1D

familial glomangioma

GCd

CLCA3

chloride channel, calcium activated

FRA1D

strictly linked to CLCA2, tumor suppressor gene for breast cancer

Oncogene 2004 (19): 1471-80

EVI-5

EVI-5 homolog

FRA1D

Cell 2006 Jan 27; 124(2): 367-80

TNFSF4

TNF(ligand) superfamily, member 4

FRA1G

leukemia T-cell, neoplasms

AGCOH, GCd

TNFSF18

TNF(ligand) superfamily, member 18

FRA1G

neoplasms

AGCOH

TNR

tenascin R

FRA1G

neoplasms

AGCOH

ANGPTL1

Angiopoietin-related protein 1 precursor

FRA1G

neoplasms

Cancer Cell 2004 Nov; 6(5):507-16

ITGAV

CD51 antigen

FRA2H

neoplasm metastasis, colon, breast and pancreatic carcinoma

Cancer Metastasis Rev 2003 Mar;22(1):103-15

FAM3D

family with sequence similarity 3, member D

FRA3B

located 900 kb, with no intervening genes, distal from FHIT gene

THPO

thrombopoietin

FRA3C

myeloproliferative disorders

AGCOH, GCd

ADIPOQ

adiponectin, C1Q and collagen domain containing

FRA3C

myeloblastic leukemia

Br J Cancer 2006 Jan 16; 94(1):156-60

AHSG

alpha-2-HS-glycoprotein

FRA3C

liver carcinoma

GCd

BCL6

B-cell CLL/lymphoma 6

FRA3C

lymphoma b-cell, lymphoma non-hodgkins, burkitt lymphoma

Oncogene 2006 Jul 3

PLG

plasminogen precursor

FRA6E

neoplasm metastasis, neoplasms vascular tissue

J Cell Biochem 2005 Oct; 96(2):242-61

HOXA5

homeo box A5

7p15.2

breast carcinoma

J Biol Chem 2000 Aug ; 275(34):26551-5

HOXA7,9

homeo box A7, A9

7p15.2

myeloid leukemia

Leuk Res 2000 Oct; 24(10): 849-55

EPO

erythropoietin

FRA7F

myelodyplastic syndromes

AGCOH, GCd

AZGP1

alpha-2-glycoprotein 1, zinc

FRA7F

cancer of breast, prostate (GCd)

AGCOH

PBEF1

pre-B-cell colony enhancing factor 1

FRA7F

myeloid leukemia

Leukemia 2005 Jun; 19(6): 998-1004

CAV-1,-2

caveolin 1, caveolin 2

FRA7G

carcinoma of colon, adenocarcinoma, ovarian epithelial carcinoma

Genomics 2003 Feb; 81(2):105-7

MET

HGF receptor

FRA7G

gastric carcinoma, neoplasm metastasis, carcinoma renal cell

Oncogene 2006 Jan 19; 25(3):409-18

INFB1

interferon beta 1

FRA9C

neoplasms, melanoma

AGCOH, GCd

IFNE1

interferon epsilon 1

FRA9C

located 350 kb distal from MTAP, CDKN2A and CGKN2B tumor genes

IFNA1

interpheron alpha 1

FRA9C

leukemia

AGCOH, GCd

IFNA2

interpheron alpha 2

FRA9C

myeloid leukemia, renal cell cancer

GCd, TGD

SMPD3

sphingomyelin phosphodiesterase 3

FRA16C

strictly linked to CDH3 (P-cadherin tumour gene)

CKLF

chemokine-like factor

FRA16C

strictly linked to CDH5 (P-cadherin tumour gene)

CES2

Carboxylesterase 2 precursor

FRA16C

malignant neoplasms, carcinoma of colon

Neoplasia 2005 Apr;7(4): 407-16

NQO1

NAD(P)H dehydrogenase, quinone 1

FRA16C

carcinoma of colon, malignant neoplasm of lung, cancer of bladder

Clin Cancer Res 2005 Dec; 11(24):8866-71

LIF

leukemia inhibitory factor

FRA22B

leukemia, myeloma, neuroepitelioma, stricltly linked to HORMAD2

AGCOH, TGD

OSM

oncostatin M

FRA22B

leukemia, myeloma, kaposi sarcoma, melanoma, plasmacitoma

AGCOH, TGD

TCN2

transcobalamin II, macrocytic anemia

FRA22B

colon adenocarcinoma

GCd

SEC14L2

SEC14-like 2

FRA22B

neoplasms

Cancer Res 2005 Nov 1; 65(21):9807-16