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Table 1 Results for predicting potential effects of experimental amino acid substitutions occurring in the E. coli lac repressor, the bacteriophage T4 lysozyme, and the mixed samples.

From: Searching for interpretable rules for disease mutations: a simulated annealing bump hunting strategy

  

Support vector machine

Random forest

  

AUC

BER

MCC

AUC

BER

MCC

Continuous

Lac repressor

0.912

0.152

0.694

0.939

0.143

0.723

 

T4 lysozyme

0.897

0.177

0.614

0.907

0.167

0.640

 

Mixed

0.889

0.185

0.612

0.921

0.158

0.678

Discrete

Lac repressor

0.905

0.170

0.654

0.944

0.125

0.741

 

T4 lysozyme

0.878

0.199

0.588

0.911

0.167

0.651

 

Mixed

0.887

0.187

0.622

0.927

0.148

0.693