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Table 4 Details of the proposed features.

From: Searching for interpretable rules for disease mutations: a simulated annealing bump hunting strategy

 

Physicochemical

Relative frequency in

Conservation

 

Molecular weight

pI value

Hydrophobicity

Helices

Strands

Turns

Frequency in MSA

Original

X 1

X 2

X 3

X 4

X 5

X 6

X 43

Substitution

X 7

X 8

X 9

X 10

X 11

X l2

X 44

Window-sized

X l3

X 14

X 15

X 16

X 17

X 18

 

Column-weighted

X 19

X 20

X 21

X 22

X 23

X 24

 

Substitution- Original

X 25

X 26

X 27

X 28

X 29

X 30

 

Substitution-Window

X 31

X 32

X 33

X 34

X 35

X 36

 

Substitution-Column

X 37

X 38

X 39

X 40

X 41

X 42

 
  1. Each of the 6 amino acid properties is calculated in 7 situations, forming X1 ~ X42, while the conservation scores for the original and the substituted amino acids become X43 and X44, respectively.
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BMC Bioinformatics

ISSN: 1471-2105

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