Figure 1

The 87 TRMs identified in this study. Each rectangle stands for a module and the ovals in a rectangle indicate the TFs that regulate the module. TF name is colored blue if its function is consistent with one of the module's over-represented MIPS functional categories with adjusted p-value < 0.05 (after the Bonferroni correction for multiple tests) using the cumulative hypergeometric distribution or black if not. Two ovals are connected by a line if previous studies indicated that the two TFs interact with each other physically (forming a protein complex), functionally (in the same cellular process) or statistically (co-occurrence) [19-22,24]. An oval is colored red (green) if the TF is identified as an activator (repressor). The periphery of a rectangle is colored purple if this module implicates important TF combinations or is discussed in the text.