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Figure 3 | BMC Bioinformatics

Figure 3

From: Rank-statistics based enrichment-site prediction algorithm developed for chromatin immunoprecipitation on chip experiments

Figure 3

Biases in the parametric binary segmentation method for detection of putative enrichment sites-II. This demonstrates a comparison of site detection in B1-3 and replicate composite(C) based on the threshold selection. Depending on the threshold and which replicate it is determined from, there is significant variation in the detection of putative sites. (Top panel) Detection threshold is determined based on B1 but applied uniformly across B1-B3 and replicate composite (C); (left) Fixed pScore threshold of σp ≥ 50; (right) A distributional threshold of σp ≥ 99th percentile of the pScore distribution. (Bottom panel) Detection threshold is determined based on replicate composite(C) but applied uniformly to all; (left) Fixed pScore threshold of σp ≥ 50; (right) A distributional threshold of σp ≥ 99th> percentile of the pScore distribution.

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