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Figure 8 | BMC Bioinformatics

Figure 8

From: Rank-statistics based enrichment-site prediction algorithm developed for chromatin immunoprecipitation on chip experiments

Figure 8

Rank Statistics based site prediction algorithm outcome for RNA pol II. Distribution of RNA pol II sites in 3 parameter p-value space (μ, SAD, ε) with the color-map indicating ranking of sites based on λ, distribution (left); SE distribution (right). This distribution is computed for data from 5 replicates. Color-map: blue and red represents the maximum and minimum bounds of the respective distributions. (Top panels) The p-value centric 3 component ranking has concordance with the SE based ranking, except for the cluster indicated by an arrow. (Center panels) Removal of sites belonging to the aberrant cluster increases the rank correlation from 81.2% to 97.5%. These sites are eliminated following the application of a SE based filter, where the SE threshold is based on the median (SETM) of the aberrant cluster. (Bottom panels) Unlike the prior distribution, this dataset reflect the presence of three distinct site clusters. This output is based on the maximally discordant triplicate experiments of the above five replicates.

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