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Table 3 The six orphan enzyme activities that are specific to Homo sapiens.

From: ORENZA: a web resource for studying ORphan ENZyme activities

EC number

Enzyme name

role in human physiology

EC 2.3.1.125

1-alkyl-2-acetylglycerol O-acyltransferase

platelet activation

EC 3.1.6.15

N-sulfoglucosamine-3-sulfatase

urinary infection by Flavobacterium heparinum

EC 1.1.1.160

dihydrobunolol dehydrogenase

liver physiology

EC 2.4.1.153

dolichyl-phosphate α-N-acetylglucosaminyltransferase

liver physiology

EC 3.1.2.13

S-succinylglutathione hydrolase

liver physiology

EC 5.1.3.19

chondroitin-glucuronate 5-epimerase

blood coagulation, cardiovascular disease, carcinogenesis