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Figure 2 | BMC Bioinformatics

Figure 2

From: An improved distance measure between the expression profiles linking co-expression and co-regulation in mouse

Figure 2

Typical co-expressed gene cluster with high correlation. The tightest gene cluster on the mice cortex developmental data is shown as a heatmap diagram; a sophisticated clustering algorithm is used with one minus correlation as the distance measure. The cluster consists 65 down regulated genes. The green column on the right side of the diagram shows the fold-change between two cortex samples at embryonic 8 days and adult age. The expression level matrix is standardized: mean subtracted and standard deviation divided; the color scheme ranges from -3 (blue, below the mean) to 3 (red, above the mean). The white color represents mean (0 value). The rows correspond to different genes, and the columns represent the experimental samples. The genes have tight linear expression pattern but their fold-changes between samples are highly variable. Such variability is a general phenomenon when one minus correlation is the distance measure.

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