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Table 3 Most abundant CB regions in Human and their significant functional associations and predicted protein disorder (*)

From: Exhaustive assignment of compositional bias reveals universally prevalent biased regions: analysis of functional associations in human and Drosophila

Bias

Number of members

Mean disorder (D) value

Functional categories

(GO term [# of occurrences]; description; P' value)

{P}

273

0.61

GO:0005737 [55]; cytoplasm (3 × 10-23)

   

GO:0007155 [28]; cell adhesion (4 × 10-10)

{C}

183

0.00

GO:0005515 [37]; protein-binding (2 × 10-4)

   

GO:0005509 [35]; calcium-ion binding (3 × 10-15)

   

GO:0007155 [29]; cell adhesion (5 × 10-16)

   

GO:0005198 [27]; structural-molecule activity (4 × 10-16)

   

GO:0046872 [21]; metal-ion binding (4 × 10-3)

   

GO:0005578 [16]; extracellular matrix (sensu Metazoa) (8 × 10-9)

{GP}

116

0.76

GO:0005737 [65]; cytoplasm (2 × 10-61)

   

GO:0007155 [27]; cell adhesion (2 × 10-19)

   

GO:0005198 [12]; structural-molecule activity (2 × 10-3)

   

GO:0005578 [9]; extracellular matrix (sensu Metazoa) (8 × 10-3)

{Q}

77

0.41

GO:0005634 [34]; nucleus (3 × 10-8)

   

GO:0006355 [21]; DNA-dependent regulation of transcription (1 × 10-4)

{S}

74

0.71

 

{G}

70

0.40

GO:0005634 [24]; nucleus (2 × 10-2)

{E}

69

0.49

GO:0005198 [10]; structural-molecule activity (1 × 10-3)

{ED}

33

0.56

GO:0005634 [24]; nucleus (1 × 10-11)

   

GO:0006355 [14]; DNA-dependent regulation of transcription (6 × 10-5)

{PG}

32

0.75

 

{QP}

30

0.52

 
  1. (*) – The CB regions are sorted in decreasing order of abundance. They are denoted by their CB signatures in column #1. Column #2 contains the total number of members in a particular cluster; column #3 is the mean value of D, the disorder fraction of each member; column #4 lists the top five significantly-associated (P' ≤ 0.05, adjusted for multiple hypothesis testing) GO (Gene Ontology terms for the cluster in the format: GO term name [count for GO term]; description of GO term in words. In addition, bias types that are significantly associated with transcription (where we reduced GO categories to just two categories, 'transcription-related' and 'non-transcription-related'), are labelled with a sign.