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Figure 3 | BMC Bioinformatics

Figure 3

From: inGeno – an integrated genome and ortholog viewer for improved genome to genome comparisons

Figure 3

Strain-specific island – investigation of pathogenicity and metabolism. The top genome is E. coli O157 [25], the lower is E. coli K-12 strain MG1655 [23-25]. The selected region (ECs1272-1296 and ECs1299-1409) is one of the strain-specific islands that are potentially related to bacterial pathogenicity. ECs1282 and ECs1283 are identified by inGeno as hemagglutinin/hemolysin-like protein and hemolysin activator-related protein, respectively. An operon-like structure follows these two genes. InGeno reports these encode for a holo acyl-carrier protein, an oxoacyl-(acyl-carrier protein) reductase, a hydroxydecanoyl-(acyl-carrier protein) dehydratase, an acyl-carrier protein, an aminomethyl transferase and an oxoacyl-(acyl-carrier protein)-synthase. These enzymes and proteins add to the fatty acid metabolism, additional lipids or lipoproteins may be produced by O157 in contrast to MG1655. Moreover, a series of continuous genes encoding urease components are shown for 0157 (ECs1321-1327: UreA-G). The detailed information on these proteins is summarized in Table 1.

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