Figure 4

Typical results from ProFAT's Threading Engine. (A) Threader alignment of the PH-domain of Dip13α/APPL1 [GenBank:NP_036228]. The Threading Engine picked up the crystal structure of the PH-domain of the protein Tiam1 ([PDB:1FOE]). Secondary structure elements are shown above the identified hit. The CATH ID, the threading score, as well as the PDB-ID are given underneath the alignment. The features, abstracts of associated publications, PDB compound information and the PDB-keywords can be individually visualized by the user. In this case, the abstract of the associated paper of 1FOE, as well as the PDB-keywords are shown. (B) Processed results of the Threader-output. In this case, the top five hits are shown, including their score, function, compound and keyword information.