Figure 7

multiple sequence alignments of weakly conserved domains. (A) Multiple sequence alignment of CH domain family members with human Hook1, Hook2 and Hook3, as well as KPL2 from human, sea urchin and C. reinhardtii. Conserved residues are highlighted in yellow, essential residues are marked with an asterix. (B) Multiple sequence alignment of Eps8 family members with representatives of the SAM domain family, with conserved residues highlighted in yellow. (C) Multiple Sequence alignment of representatives of the RRM domain family with members of the PARN family, as well as human unknown protein LOC84060 and its orthologues from zebrafish and fly. Conserved residues are highlighted in yellow. (D) Multiple sequence alignment of human, fly and worm orthologues of unknown protein LOC79969 with representatives of the acetyltransf_1 domain family. Conserved residues are highlighted in yellow, the catalytically important Tyrosine is marked with an asterix. For accession numbers of all proteins shown in alignments A – D, see [Additional file 10].