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Table 3 The mean square errors of estimated gene expression levels for simulated cDNA microarray data with differentially expressed genes inserted under the medium expression levels condition.

From: Evaluating different methods of microarray data normalization

Percentage of DEG

 

Sinusoid

Banana

Mixed

 

Method

25% Quantile

Median

75% Quantile

25% Quantile

Median

75% Quantile

25% Quantile

Median

75% Quantile

5%

Loess

0.00356

0.00373

0.00389

0.00379

0.00392

0.00407

0.05214

0.05234

0.05259

 

Splines

0.00354

0.00370

0.00387

0.00379

0.00393

0.00407

0.05237

0.05258

0.05283

 

Wavelets

0.00351

0.00368

0.00384

0.00438

0.00450

0.00466

0.05227

0.05247

0.05272

 

Kernel

0.03799

0.03816

0.03838

0.17380

0.17441

0.17487

0.18858

0.18882

0.18904

 

SVR

0.00337

0.00353

0.00369

0.00357

0.00368

0.00382

0.05034

0.05049

0.05067

10%

Loess

0.00709

0.00723

0.00743

0.00758

0.00780

0.00799

0.05483

0.05506

0.05532

 

Splines

0.00707

0.00721

0.00741

0.00763

0.00787

0.00805

0.05507

0.05532

0.05556

 

Wavelets

0.00705

0.00718

0.00739

0.00858

0.00881

0.00898

0.05497

0.05522

0.05547

 

Kernel

0.03837

0.03857

0.03886

0.15366

0.15461

0.15523

0.18801

0.18830

0.18867

 

SVR

0.00672

0.00688

0.00707

0.00709

0.00731

0.00750

0.05150

0.05164

0.05183

15%

Loess

0.01041

0.01061

0.01094

0.01108

0.01136

0.01165

0.05964

0.05985

0.06012

 

Splines

0.01039

0.01060

0.01091

0.01109

0.01136

0.01165

0.05990

0.06013

0.06039

 

Wavelets

0.01038

0.01058

0.01089

0.01251

0.01276

0.01310

0.05978

0.06003

0.06029

 

Kernel

0.03867

0.03897

0.03927

0.12923

0.13026

0.13111

0.19337

0.19367

0.19414

 

SVR

0.00986

0.01006

0.01032

0.01027

0.01056

0.01081

0.05499

0.05526

0.05550

20%

Loess

0.01393

0.01418

0.01444

0.01487

0.01519

0.01542

0.06362

0.06398

0.06432

 

Splines

0.01393

0.01415

0.01442

0.01486

0.01518

0.01542

0.06390

0.06425

0.06460

 

Wavelets

0.01390

0.01414

0.01440

0.01631

0.01666

0.01689

0.06375

0.06410

0.06445

 

Kernel

0.03915

0.03957

0.04004

0.12265

0.12366

0.12464

0.19808

0.19858

0.19909

 

SVR

0.01310

0.01334

0.01365

0.01365

0.01399

0.01416

0.05809

0.05835

0.05858

40%

Loess

0.02772

0.02813

0.02862

0.02969

0.03004

0.03043

0.07856

0.07910

0.07975

 

Splines

0.02774

0.02814

0.02861

0.02966

0.03002

0.03038

0.07884

0.07937

0.08002

 

Wavelets

0.02771

0.02811

0.02859

0.03012

0.03049

0.03092

0.07873

0.07926

0.07995

 

Kernel

0.04195

0.04261

0.04316

0.15640

0.15816

0.16012

0.20368

0.20443

0.20518

 

SVR

0.02545

0.02581

0.02614

0.02656

0.02685

0.02724

0.06786

0.06830

0.06862

  1. DEG: Differentially expressed genes