Figure 1

Estimation of kinase substrate prediction probabilities. The analysis is based on Scansite [11] scores. Diamonds, the probability (A) that a phosphorylation site is associated with a particular protein kinase, where the protein is a known substrate but the phosphorylation site is unknown, as a function of Scansite score. Squares, the probability (B) that a protein kinase is associated with a particular substrate protein, where the phosphorylation site is known but the protein kinase is unknown, as a function of Scansite score. The lines are 3rd order polynomials that best fit the data (dashed, probability A; solid, probability B).