Protein kinases associated with the yeast phosphoproteome

BMC Bioinformatics

Table 1 Classification of protein kinases of *S. cerevisiae**

Group or family	Group or family name	Example protein kinase	Number of protein kinases	Number of phosphorylation sites predicted
Group I	AGC kinases (PKA, PKG, PKC)		17	36
I_A, I_C, I_F	cAMP-dependent protein kinases	Sch9p	9
I_B	Protein kinase C (Pkc1p) family	Pkc1p	1
I_D	Ribosomal S6 kinase family	Kin82p	2
I_E	Dbf2p family	Dbf2p	2
I_G	Other AGC kinases	Yfl033cp	3
Group II	CaMKs		17	24
II_A	Kinases regulated by calcium/calmodulin	Cmk1p	4
II_B	5'AMP activated kinase family	Snf1p	6
II_C	Nim1p family	Hsl1p	3
II_D	Other CaMKs	Dun1p	4
Group III	Pro-directed (CMGC) kinases		21	23
III_A	Cyclin-dependent kinases	Cdc28p	5
III_B	Mitogen-activated kinases (MAPKs)	Slt1p	6
III_C	Glycogen synthase kinase 3β	Mds1p	4
III_D	CDK-like kinases (CLKs)	Yak1p	4
III_E	Other CMGC kinases	Sgv1p	2
Group IV	Ste11p/Ste20p (MAPKKKs)		10	26
IV_A	Ste11p family	Bck1p	4
IV_B	Ste20p family	Cla4p	3
IV_C	NRK Family	Cdc15p	3
Group V	Ste7p/NEK (MAPKKs)		8	32
V_A	Ste7p family	Ste7p	4
V_B	NIMA (NEK) family	Kin3p	1
V_C	NEK-like family	Akl1p	3
Group VI	Other kinases		24	96
VI_A	CK1 family	Yck1p	4
VI_B	CK2 family	Cka1p	3
VI_C	Npk1p/Hal5p family	Ptk1p	9
VI_D	Elm1p family	Pak1p **	3
VI_E	Ran1p family	Sha3p	3
VI_F	Pim1p-like family	Yal017wp	2
Group VII	Unique kinases		19	38
VII_A	With possible homologues	Rad53p	14
VII_B	With no known homologues	Bub1p	5

* Based on [1].
** There are two protein kinases designated Pak1p in S. cerevisiae; in this manuscript, Pak1p from group VI_D is referred to as Pak1p (Yer129wp), while Pak1p from group V_C is referred to as Prk1p (Pak1p).

ISSN: 1471-2105