Topological basis of signal integration in the transcriptional-regulatory network of the yeast, Saccharomyces cerevisiae

Table 1 Number distributions and statistical significance of 3-node subgraphs in yeast TR network

Subgraph
Number in the original network	150 845	2 898	2 655	392	307	118
After link randomization	151 477 ± 152	3 543 ± 156	2 996 ± 23	176 ± 22	126 ± 148	2.6 ± 3.9
Significance of original (Z score)	-4.2	-4.1	-15	9.7	1.2	30
Subgraph type	Anti-motif	Anti-motif	Anti-motif	Motif	Motif	Motif

Motifs are marked, and only subgraphs with at least 100 occurrences in the original network are listed. After link randomization the numbers of FFL, SMR and CMR subgraphs decrease, while those of DIV, CAS, and CNV subgraphs are maintained with slight increases, indicating that FFL, SMR and CMR are motifs in the TR network, while DIV, CAS and CNV are anti-motifs [8,18].

ISSN: 1471-2105