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Figure 3 | BMC Bioinformatics

Figure 3

From: RiboSubstrates: a web application addressing the cleavage specificities of ribozymes in designated genomes

Figure 3

Design of RiboSubstrates with the parameters for the hammerhead ribozyme. (A) Secondary structure and nucleotide sequence of the hammerhead ribozyme targeting an mRNA. The two binding domains of the ribozyme are identified. The letter N indicates the presence of an A, C, G or T residue. The arrow indicates the cleavage site. (B) The RiboSubstrates input with the signature to be searched for the hammerhead ribozyme targeting the Homo sapiens Bcl-2 mRNA (hhRz-Bcl-2-1). Mismatched nucleotides and Wobble base pairs are identified in red and blue, respectively. (C) The substrate display table retrieved for this ribozyme.

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BMC Bioinformatics

ISSN: 1471-2105

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