Figure 12
From: Novel metaheuristic for parameter estimation in nonlinear dynamic biological systems
Three-step biochemical pathway scheme. The pathway substrate (S) and the product (P) are held at constant concentrations; Ml and M2 are intermediate metabolites of the pathway; El, E2, and E3 are the enzymes and G1, G2, and G3 are the mRNA species for the enzymes. Solid arrows indicate mass transfer reactions and point to the positive direction of flux but are chemical reversible. Dashed arrows indicate activation and dashed curves with blunt ends indicate inhibition.