Figure 7From: Novel metaheuristic for parameter estimation in nonlinear dynamic biological systemsMechanism of irreversible inhibition of HIV proteinase. The HIV proteinase (E) was added to a solution of an irreversible inhibitor (I) and a fluorogenic substrate (S). The enzyme is only active in a dimer form, the product is a competitive inhibitor for the substrate and the inhibitor is irreversible.Back to article page