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Table 3 Predictive results obtained by using various similarity definitions for proteins

From: Assessing protein similarity with Gene Ontology and its use in subnuclear localization prediction

Similarity Definition

MAX

AVG

SUM

AVG_BestPairs

Compartment

MCC (Accuracy %)

PML BODY

0.189 (28.9)

0.153 (34.2)

0.129 (76.3)

-0.031 (0.0)

Nuclear Lamina

0.344 (45.5)

0.535 (63.6)

0.455 (45.5)

0.315 (61.8)

Nuclear Splicing Speckles

0.377 (35.7)

0.251 (71.4)

0.289 (33.9)

0.013 (12.5)

Chromatin

0.236 (19.7)

0.218 (16.4)

0.112 (4.9)

0.142 (8.2)

Nucleoplasm

0.272 (29.3)

0.039 (9.3)

-0.079 (4.0)

0.118 (6.7)

Nucleolus

0.367 (75.8)

0.431 (44.7)

0.214 (26.0)

0.289 (75.3)

Overall for Single-localization

0.298 (50.8)

0.271 (40.3)

0.187 (27.0)

0.141 (42.9)

Similarity Definition

SUM_BestPairs

AVG_Match

SUM_Match

MAX_Match

Compartment

MCC (Accuracy %)

PML BODY

0.242 (44.7)

0.187 (34.2)

0.253 (34.2)

0.211 (31.6)

Nuclear Lamina

0.53 (67.3)

0.586 (60.0)

0.578 (63.6)

0.344 (45.5)

Nuclear Splicing Speckles

0.438 (46.4)

0.397 (66.1)

0.607 (62.5)

0.487 (46.4)

Chromatin

0.325 (36.1)

0.467 (45.9)

0.518 (60.7)

0.263 (21.3)

Nucleoplasm

0.284 (36.0)

0.332 (32.0)

0.504 (56.0)

0.298 (32.0)

Nucleolus

0.512 (66.7)

0.615 (72.6)

0.656 (79.0)

0.407 (76.7)

Overall for Single-localization

0.388 (54.6)

0.431 (58.3)

0.519 (66.5)

0.335 (53.2)

  1. (Based on SimLP: The GO term similarity is defined on the longest path shared by two GO terms [22].)