Skip to main content

Table 5 Results of SKM on multiple MHC Class II alleles from MHCPEP

From: Predicting Class II MHC-Peptide binding: a kernel based approach using similarity scores

MHC Allele Species #Samp β Acc. Spec. Sens. AROC AROC50 MCC AOVER-ROC
HLA-DR11 Human 1346 0.04 0.9123 0.9153 0.9094 0.9712 0.8460 0.8247 0.0288
- *0101   474 0.06 0.8987 0.9114 0.8861 0.9673 0.8864 0.7977 0.0327
- *0102   12 0.005 0.8333 0.6667 1 0.9444 0.9444 0.7071 0.0556
HLA-DR21 Human 648 0.15 0.9059 0.9692 0.8426 0.9608 0.8701 0.8183 0.0392
- *0201   44 0.8 0.8864 0.9091 0.8636 0.9360 0.9360 0.7735 0.0640
HLA-DR31 Human 378 0.15 0.9101 0.9577 0.8624 0.9750 0.9216 0.8239 0.0250
- *0301   242 0.02 0.9339 0.9008 0.9669 0.9847 0.9676 0.8697 0.0153
HLA-DR41 Human 1742 0.125 0.9248 0.9460 0.9036 0.9749 0.8677 0.8504 0.0251
- *0401   910 0.125 0.8890 0.9187 0.8593 0.9521 0.7989 0.7794 0.0479
- *0402   240 0.07 0.9 0.925 0.875 0.9717 0.9365 0.8010 0.0282
HLA-DR5 Human 398 0.125 0.9171 0.9799 0.8542 0.9717 0.9166 0.8408 0.0283
HLA-DR6 Human 46 0.25 0.9348 1 0.8696 0.9981 0.9981 0.8771 0.0019
HLA-DR7 Human 528 0.1 0.9034 0.9659 0.8409 0.9696 0.8965 0.8132 0.0304
HLA-DR8 Human 160 0.06 0.8938 0.8625 0.925 0.9683 0.9505 0.7890 0.0317
HLA-DR9 Human 192 0.2 0.9375 0.9896 0.8854 0.9779 0.9575 0.8798 0.0221
HLA-DR10 Human 12 5 0.5833 0.6667 0.5 0.6389 0.6389 0.1690 0.3611
HLA-DR11 Human 590 0.03 0.9169 0.9390 0.8949 0.9615 0.8847 0.8347 0.0385
HLA-DR14 Human 126 1 0.9762 1 0.9524 0.9934 0.9917 0.9535 0.0066
HLA-DR17 Human 308 0.03 0.9448 0.9545 0.9351 0.9802 0.9579 0.8898 0.0198
HLA-DR53 Human 72 0.2 0.8889 1 0.7778 0.9931 0.9931 0.7977 0.0069
HLA-DP9 Human 90 0.2 0.9889 0.9778 1 1 1 0.9780 0
HLA-DPw4 Human 38 0.01 0.7895 0.8421 0.7368 0.9058 0.9058 0.5822 0.0942
HLA-DQ1 Human 78 0.02 0.8974 0.9231 0.8718 0.9579 0.9579 0.7959 0.0420
HLA-DQ2 Human 210 0.08 0.8952 0.9714 0.8190 0.9664 0.936 0.7998 0.0336
HLA-DQ4 Human 194 0.2 0.8866 0.8969 0.8763 0.9557 0.9188 0.7734 0.0443
Weighted average   363.12 0.120 0.9120 0.9390 0.8850 0.9687 0.8852 0.8263 0.0313
  1. Evaluating performance on multiple alleles using 10-fold CV. Average scores shown underneath, weighted by number of samples.
  2. 1All binders belonging to a group of alleles.