TY - JOUR AU - Hallén, Kristofer AU - Björkegren, Johan AU - Tegnér, Jesper PY - 2006 DA - 2006/02/02 TI - Detection of compound mode of action by computational integration of whole-genome measurements and genetic perturbations JO - BMC Bioinformatics SP - 51 VL - 7 IS - 1 AB - A key problem of drug development is to decide which compounds to evaluate further in expensive clinical trials (Phase I- III). This decision is primarily based on the primary targets and mechanisms of action of the chemical compounds under consideration. Whole-genome expression measurements have shown to be useful for this process but current approaches suffer from requiring either a large number of mutant experiments or a detailed understanding of the regulatory networks. SN - 1471-2105 UR - https://doi.org/10.1186/1471-2105-7-51 DO - 10.1186/1471-2105-7-51 ID - Hallén2006 ER -