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Figure 4 | BMC Bioinformatics

Figure 4

From: Detection of compound mode of action by computational integration of whole-genome measurements and genetic perturbations

Figure 4

CutTree analysis of data on the Yeast galactose response. CutTree analysis of data on the Yeast galactose response from Ideker et al, which showed that in wild-type S. cerevisiae, expose to galactose alters the expression of 952 genes. GAL2 encodes a transporter that brings galactose into the cell. GAL1, GAL7, and GAL10 encode proteins involved in the conversion of intracellular galactose, and GAL3, GAL4, and GAL80 encode proteins that control the transcription of other GAL genes and each other. When galactose is present, Gal3 binds to Gal80, releasing the repression of Gal4 and starting the transcription of enzymatic and transporter genes. Application of CutTree to the data generated a PAG hierarchy. In the top three levels of the hierarchy, four of five genes identified by CutTree are known PAGs.

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