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Table 3 Number of additional direction assignments required to eliminate remaining thermodynamically infeasible energy production

From: Systematic assignment of thermodynamic constraints in metabolic network models

common attributes

standard procedure

standard procedure with consideration of final electron acceptors

quinone pool reductions

15

-

transporters

9

8

NTP production

14

12

NADH/NADPH production

5

4

O2 production

2

1

CO2 consumption

4

4

NMP synthesis

7

7

other

3

3

sum

59

39