Cis-motifs upstream of the transcription and translation initiation sites are effectively revealed by their positional disequilibrium in eukaryote genomes using frequency distribution curves

Table 5 Number of known functional cis-regulatory elements (CRE) that have positional disequilibria.

Dataset	Number of Cis-elements	number over 6-SD	sing.ori/both.ori/palindrome	percentage over 6-SD
Dm TSS	87	13	2/10/1	14,94%
Dm ATG	87	14	8/5/1	16,09%
	Dm shared	12	6/5/1	13,79%
At TSS	450	77	33/35/9	17,11%
At ATG	450	71	38/27/6	15,78%
	At shared	33	11/17/5	7,33%
Ce TSS	87	7	7/0/0	8,05%
Ce ATG	87	44	26/16/2	50,57%
	Ce shared	7	7/0/0	8,05%
Sc ATG	51	16	7/8/1	31,37%

Cis-elements [see Additional File 5] were retrieved and tested for positional disequilibrium as described in the text. CREs were analyzed for orientation bias (sing. ori = present in one orientation, both ori. = present in both orientations, or a palindrome). Percentage is the proportion of CREs relative to the respective total number of cis-elements investigated [see Additional File 12].

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