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Table 2 The hyperarcs of the logical T-cell signaling model (see Figure 10). Exclamation mark ('!') denotes a logical NOT and dots within the equations indicate AND operations.

From: A methodology for the structural and functional analysis of signaling and regulatory networks

→ CD45
→ CD8
→ TCRlig
AP1 →
Ca → Calcin
Calcin → NFAT
CRE →
CREB → CRE
DAG → PKCth
ERK → Fos
ERK → Rsk
Fyn → PAGCsk
Fyn → TCRphos
Gads → SLP76
Grb2Sos → Ras
!IkB → NFkB
!IKKbeta → IkB
IP3 → Ca
JNK → Jun
Jun·Fos → AP1
LAT → Gads
LAT → Grb2Sos
LAT → PLCgbind
Lck·CD45 → Fyn
Lck → Rlk
MEK → ERK
NFAT →
NFkB →
!PAGCsk·CD8·CD45 → Lck
PKCth·DAG → RasGRP1
PKCth → IKKbeta
PKCth → SEK
PLCg(act) → DAG
PLCg(act) → IP3
Raf → MEK
Ras → Raf
RasGRP1 → Ras
Rsk → CREB
SEK → JNK
TCRbind·CD45 → Fyn
TCRbind·Lck → TCRphos
!TCRbind → PAGCsk
TCRlig·!cCbl → TCRbind
TCRphos·Lck·!cCbl → ZAP70
ZAP70·SLP76·PLCg(bind)·Itk → PLCg(act)
ZAP70·SLP76 → Itk
ZAP70 → cCbl
ZAP70 → LAT
ZAP70·SLP76·Rlk·PLCg(bind) → PLCg(act)