Table 2 The hyperarcs of the logical T-cell signaling model (see Figure 10). Exclamation mark ('!') denotes a logical NOT and dots within the equations indicate AND operations.
From: A methodology for the structural and functional analysis of signaling and regulatory networks
→ CD45 |
|---|
→ CD8 |
→ TCRlig |
AP1 → |
Ca → Calcin |
Calcin → NFAT |
CRE → |
CREB → CRE |
DAG → PKCth |
ERK → Fos |
ERK → Rsk |
Fyn → PAGCsk |
Fyn → TCRphos |
Gads → SLP76 |
Grb2Sos → Ras |
!IkB → NFkB |
!IKKbeta → IkB |
IP3 → Ca |
JNK → Jun |
Jun·Fos → AP1 |
LAT → Gads |
LAT → Grb2Sos |
LAT → PLCgbind |
Lck·CD45 → Fyn |
Lck → Rlk |
MEK → ERK |
NFAT → |
NFkB → |
!PAGCsk·CD8·CD45 → Lck |
PKCth·DAG → RasGRP1 |
PKCth → IKKbeta |
PKCth → SEK |
PLCg(act) → DAG |
PLCg(act) → IP3 |
Raf → MEK |
Ras → Raf |
RasGRP1 → Ras |
Rsk → CREB |
SEK → JNK |
TCRbind·CD45 → Fyn |
TCRbind·Lck → TCRphos |
!TCRbind → PAGCsk |
TCRlig·!cCbl → TCRbind |
TCRphos·Lck·!cCbl → ZAP70 |
ZAP70·SLP76·PLCg(bind)·Itk → PLCg(act) |
ZAP70·SLP76 → Itk |
ZAP70 → cCbl |
ZAP70 → LAT |
ZAP70·SLP76·Rlk·PLCg(bind) → PLCg(act) |