Table 3 All negative and positive feedback loops in the T-cell model as determined by CellNetAnalyzer. Negative influences are indicated by "⊣", positive influences are expressed by "→".
From: A methodology for the structural and functional analysis of signaling and regulatory networks
1 (negative) | TCRbind → TCRphos → ZAP70 → cCbl ⊣ TCRbind |
|---|---|
2 (negative) | TCRbind → Fyn → TCRphos → ZAP70 → cCbl ⊣ TCRbind |
3 (negative) | TCRbind ⊣ PAGCsk ⊣ Lck → ZAP70 → cCbl ⊣ TCRbind |
4 (negative) | TCRbind ⊣ PAGCsk ⊣ Lck → TCRphos → ZAP70 → cCbl ⊣ TCRbind |
5 (negative) | PAGCsk ⊣ Lck → Fyn → PAGCsk |
6 (negative) | TCRbind ⊣ PAGCsk ⊣ Lck → Fyn → TCRphos → ZAP70 → cCbl ⊣ TCRbind |
7 (negative) | cCbl ⊣ ZAP70 → cCbl |
8 (positive) | TCRbind → Fyn → PAGCsk ⊣ Lck → TCRphos → ZAP70 → cCbl ⊣ TCRbind |
9 (positive) | TCRbind → Fyn → PAGCsk ⊣ Lck → ZAP70 → cCbl ⊣ TCRbind |