Skip to main content

Table 3 All negative and positive feedback loops in the T-cell model as determined by CellNetAnalyzer. Negative influences are indicated by "", positive influences are expressed by "→".

From: A methodology for the structural and functional analysis of signaling and regulatory networks

1 (negative) TCRbind → TCRphos → ZAP70 → cCbl TCRbind
2 (negative) TCRbind → Fyn → TCRphos → ZAP70 → cCbl TCRbind
3 (negative) TCRbind PAGCsk Lck → ZAP70 → cCbl TCRbind
4 (negative) TCRbind PAGCsk Lck → TCRphos → ZAP70 → cCbl TCRbind
5 (negative) PAGCsk Lck → Fyn → PAGCsk
6 (negative) TCRbind PAGCsk Lck → Fyn → TCRphos → ZAP70 → cCbl TCRbind
7 (negative) cCbl ZAP70 → cCbl
8 (positive) TCRbind → Fyn → PAGCsk Lck → TCRphos → ZAP70 → cCbl TCRbind
9 (positive) TCRbind → Fyn → PAGCsk Lck → ZAP70 → cCbl TCRbind