Figure 2

Results of the single-marker mapping (SMM) method for HDLC. The upper bar chart shows the computed HDLC phenotype association profile using the parametric SMM method. The lower bar chart shows the maximum LOD scores at previously known intervals (95% confidence intervals shown as red rectangles) [16]. The x-axis indicates the genomic axis, where chromosomal boundaries are indicated by the center bar. The maximum LOD scores are cut off at 12. Association scores below 3 and LOD scores below 3.3 are not shown. Peaks on the X chromosome are ignored, and multiple peaks within a 5MB window are only counted once. Of the twenty loci with the highest association score, eleven intersect previously known QTL intervals.