Computational models with thermodynamic and composition features improve siRNA design

BMC Bioinformatics

Table 2 Determination of position-dependent nucleotide preferences and avoidances by t-test analysis.

Nucleotide and position		t-test p-value	Average activity if this nucleotide is:
Preferred	Avoided		present	absent
U1		5.6e-13	29.78	47.49
	C1	3e-07	53.04	38.64
C19		2.9e-06	34.19	45.95
	A19	2.1e-05	51.80	39.84
	G1	8.3e-05	51.59	39.94
U13		0.00058	36.39	45.03
U2		0.00108	37.17	44.75
	G2	0.00155	49.75	40.49
	G7	0.00209	48.71	40.42
A7		0.00253	36.15	44.11
U7		0.00296	37.43	44.65
	G13	0.00433	47.84	40.78
A1		0.00523	37.31	44.04
	G6	0.00557	48.24	40.69
A10		0.00573	36.61	43.96
U14		0.00633	37.75	44.27
C17		0.00768	37.49	44.04
	C7	0.00854	47.67	40.79
A14		0.00972	37.36	43.83
	A17	0.01011	47.54	40.73
	A5	0.0104	47.31	40.85
	G14	0.01121	47.59	40.88
U3		0.01599	38.01	44.03
C18		0.01653	38.35	44.03
	C14	0.02243	46.65	40.87
	A11	0.02601	47.00	41.20
U5		0.02657	39.01	44.06
	G16	0.02902	46.56	41.09
	U19	0.02982	46.47	41.09

ISSN: 1471-2105