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Table 3 Correlation of thermodynamic stability difference of the 5'/3' ends of siRNA duplexes with siRNA activity (AS) and with the ratio between the antisense strand and sense strand activities (AS/SS). Differences in the stability of the 5' and 3' ends were calculated for 2 (Diff2), 3 (Diff3), 4 (Diff4) and 5 (Diff5) terminal nucleotides in siRNA duplexes.

From: Computational models with thermodynamic and composition features improve siRNA design

Data set Activity or ratio Correlation coefficients Reference
   Diff2 Diff3 Diff4 Diff5  
28 siRNAs AS -0.245 -0.196 -0.171 -0.103 Hu et al. [11]
28 siRNAs AS/SS -0.384 -0.356 -0.368 -0.278 Hu et al. [11]
18 siRNAs AS -0.870 -0.869 -0.748 -0.767 Schwartz et al. [3]
18 siRNAs AS/SS -0.629 -0.544 -0.471 -0.453 Schwartz et al. [3]
653 siRNAs AS -0.356 -0.332 -0.292 -0.228 This work