Figure 1From: In search of functional association from time-series microarray data based on the change trend and level of gene expressionIllustration of calculating the change trend score sc and the correlation coefficient cc of the match change trend. The two genes X and Y in this example have a positive relationship (here expression levels are not normalized). Only the change trend between time points 5 and 6 is different. The number of matched change after time shifts (by dynamic programming) is less than 7. Thus, the maximal match change trend score sc is 7 in this example with 9 time points. To calculate the correlation coefficient, we first extract the change levels of the matched change trends: X m c 1 2 = 1 , X m c 2 3 = 1 , X m c 3 4 = − 1 , X m c 4 5 = 2 , X m c 5 6 = 4 , X m c 6 7 = − 2 , X m c 7 8 = 3 Y m c 1 2 = 1 , Y m c 2 3 = 1 , Y m c 3 4 = − 1 , Y m c 4 5 = 2 , Y m c 5 6 = 3 , Y m c 6 7 = − 3 , Y m c 7 8 = 4 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=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@AB67@ The change level between time points 5 and 6 is excluded because the change (inverted) trend is different from the main (positive) change trend. Using the above matched change levels we can obtain a correlation coefficient cc = 0.9597 according to Eq.1.Back to article page