An all against all VisANT http://visant.bu.edu screen shot, at C* = 0.55, of the 4286 orthologs in the COG database. 926 genes (677 annotated; 249 unannotated) are linked to at least one annotated gene. Each gene is unambiguously assigned to a unique COG functional category. Of the 677 annotated genes, 463 are correctly assigned; In total 1843 out of 4286 orthologs are unannotated in the COG classification. (A) Complete 926 gene network. (B) meta-network of genes from (A). Each group represents a set of genes allocated to a COG functional category using CE. (C) Detail of functional category H, coenzyme metabolism. (D). Of the 926 linked genes, 82 are in category H. 62 of them are true positives (green) and 8 are predictions (red). The remaining 12 are annotated in a different functional category and are therefore putative false positives. The minimum PPV for category H is therefore 62/74 = 0.84 the averaged PPV for all categories is estimated to be 68% from all annotated genes. Refer to the COG web site for definitions of categories.