Figure 7
From: Gene annotation and network inference by phylogenetic profiling
Evolutionarily conserved densely connected clusters. Edge coding: black, C* = 0.91 (p* = 10-18); yellow, C* = 0.81 (p* = 10-16); blue, C* = 0.71 (p* = 10-14). Green nodes correctly annotated; red nodes unannotated. (a) One of 4 cliques uncovered at C* = 0.91. All genes are known and are in the flagella assembly pathway. (b) One of 9 clusters at C* = 0.81, ranging in size from 4 to 13 nodes. In the cluster shown, all genes are annotated to the KEGG histidine metabolism pathway and to the COG amino acid metabolism and transport category. (c) – (e) are examples of mixed annotated-unannotated clusters, with the annotated sets homogeneous in function. Lower bounds on PPV for assigned functions are 79% (C* = 0.71) and 89% (C* = 0.81).