Figure 1

"Up-Up-Up" Temporal Pattern of Microarray Gene Expression in U-937 Cells. The figure demonstrates the clustering of genes sharing the pattern of steadily increasing expression level for RNA following treatment with ATRA as measured by microarray. Two subclones of U937 cells are shown, "Minus" and "Plus", over the time course of 0, 6, 24, and 48 hrs. [For all eight clusters for both subclones see Additional File 2.]