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Table 2 Area under the ROC curve derived from different stages of the CARAT method.

From: CARAT: A novel method for allelic detection of DNA copy number changes using high density oligonucleotide arrays

Area under ROC Curve 1X 3X 4X 5X
Stage 1 0.6240 0.5188 0.6575 0.7863
Stage 2 0.6732 0.5384 0.6840 0.8128
Stage 3 0.9319 0.8987 0.9546 0.9877
Stage 4 0.9887 0.9759 0.9974 0.9995
Stage 5 0.9999 0.9999 1.0000 1.0000
  1. Note:
  2. 1The specificity is estimated using the 47 female samples that are a subset of the 90 normal test set samples and is restricted to the 1955 X chromosome SNPs. The sensitivity is estimated on 1955 X chromosome SNPs using DNA samples with 1X, 3X, 4X and 5X chromosomes.
  3. 2Stage 1: Single point analysis: no probe selection, no intensity adjustment on fragment length and GC content; no intensity adjustment on reference mean.
  4. 3Stage 2: Stage 1 plus probe selection.
  5. 4Stage 3: Stage 2 plus intensity adjustment on the fragment length and GC content and intensity adjustment on the reference mean.
  6. 5Stage 4: Stage 3 plus kernel smoothing with a 100 kb window.
  7. 6Stage 5: Stage 4 plus genome partitioning using the regression tree.