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Table 6 Allele specific Taqman results

From: CARAT: A novel method for allelic detection of DNA copy number changes using high density oligonucleotide arrays

  

Sample

SK-BR-3

ZR-75-30

SNPID

Chr

Pos

P-Value

CN_A

CN_B

DM Call

P-Value

CN_A

CN_B

DM Call

1724728

4

9565339

0.0001

0.89 (0.85)

0.22 (0.0)

AA

0.0006

1.77 (1.5)

0.19 (0.02)

NC

1726250

8

89504951

<10-20

0.83 (0.97)

14.83 (10.8)

BB

0.141

0.43 (0.0)

0.84 (1.21)

BB

1700191

8

112018158

5.03 × 10-11

0.34 (0.08)

4.57 (5.54)

BB

3.77 × 10-19

0.81 (0.01)

8.99 (8.93)

BB

1746553

8

120342175

1.72 × 10-20

18.45 (14.32)

1.17 (1.43)

AA

8.09 × 10-20

10.44 (5.7)

1.19 (0.68)

AA

1710029

8

121176983

1.53 × 10-20

19.05 (35.5)

3.30 (1.02)

AA

3.61 × 10-20

13.60 (9.1)

2.46 (0.77)

NC

1736669

12

41456018

0.843

1.10 (1.08)

0.90 (0.99)

NC

0.075

1.68 (1.61)

1.39 (0.03)

AA

1693987

17

39301708

1.38 × 10-16

6.20 (10.64)

0.28 (0.28)

AA

0.002

0.08 (0.0)

1.06 (0.66)

NC

1718017

17

48767363

0.0001

0.93 (0.9)

0.15 (0.0)

NC

5.96 × 10-19

6.53 (5.58)

2.04 (1.12)

NC

1670177

19

20287003

1.01 × 10-9

0.0 (0.0)

0.03 (0.0)

NC

0.310

0.11 (0.36)

1.47 (0.74)

NC

  1. Note: WGSA results for 9 SNPs are shown in columns labeled CN_A (copy number of A allele) and CN_B (copy number of B allele). Allelic copy number estimates by TaqMan reactions are shown in parentheses. DM Call refers to the genotype call made using the Dynamic Model algorithm (DM) using a confidence rank score of 0.05. The VIC reporter dye was measuring the A allele for all SNPs except SNP 1710029 (B allele). The FAM reporter dye was measuring the B allele for all SNPs except SNP 1710029 (A allele).