Precision vs. Recall for 1,000 samples generated from the Mendes network. (a) Erdös-Rényi network topology. (b) Scale-free topology. ARACNE's PRCs are consistently better than those of the other algorithms, and the precision reaches ~100% while maintaining high recall. Points on the PRCs for ARACNE and RNs corresponding to p0 = 10-4 (the value yieding <0.5 expected false positives for 4,950 potential interactions) are indicated with arrows.