Figure 1From: A method for computing the overall statistical significance of a treatment effect among a group of genesCumulative distribution of p-values for one-sided test case with sample size n = 5. The corrected p-values based on a t-distribution (blue line) and the (green line) are near diagonal, while the naïve p-value (cyan line) overstates the significance of the test. We can correct the problem when we know the true correlation, R between the genes in a GO term (red line).Back to article page