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Table 1 Summary of independent mutations in the liver cII gene from comfrey-fed and control Big Blue rats

From: Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)

Type of mutation

Control *

8% comfrey •

2% comfrey •, *

 

Number

%

Number

%

Number

%

G:C → C:G

5

11

6

6

11

6

G:C → A:T

20

43

11

11

24

12

G:C → T:A

9

20

40

41

83

42

A:T → T:A

1

2

4

4

5

2

A:T → G:C

1

2

6

6

9

4

A:T → C:G

3

7

4

4

7

3

Frameshift

7

15

14

14

26

13

Complex

0

0

1

1

2

1

Tandem-base substitution

0

0

13

13

33

17

Total mutants screened

46

100

99

100

200

100

  1. •Spectra for 2% and 8% comfrey-fed rats were significantly different from the controls (P < 0.001). There was no significant difference between the spectra for 2% and 8% comfrey.
  2. *Data are from literature [10].