Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)

Mei, Nan; Guo, Lei; Zhang, Lu; Shi, Leming; Sun, Yongming Andrew; Fung, Chris; Moland, Carrie L; Dial, Stacey L; Fuscoe, James C; Chen, Tao

doi:10.1186/1471-2105-7-S2-S16

Table 2 Genes involved in drug metabolism altered by comfrey treatment in liver

From: Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)

Gene symbol	Gene description	Locus link ID	Fold change	P-value
Phase I metabolism
Cyp2c	cytochrome P450, family 2, subfamily c	29277	0.03	0.00000
Cyp2c12	cytochrome P450, family 2, subfamily c	25011	6.52	0.00000
Cyp2c39	cytochrome P450, family 2, subfamily c	29298	0.35	0.00001
Cyp2d1	cytochrome P450, family 2, subfamily d	266684	0.38	0.00000
Cyp2d2	cytochrome P450, family 2, subfamily d	25053	0.43	0.00002
Cyp2d3	cytochrome P450, family 2, subfamily d	24303	0.39	0.00000
Cyp2d5	cytochrome P450, family 2, subfamily d	286963	0.44	0.00000
Cyp3a18	cytochrome P450, family 3, subfamily a	252931	0.38	0.00060
Cyp4a3	cytochrome P450, family 4, subfamily a	298423	0.46	0.00010
Cyp4a12	cytochrome P450, family 4, subfamily a	266674	0.36	0.00015
Cyp4b1	cytochrome P450, family 4, subfamily b	24307	0.32	0.00008
Cyp4f5	cytochrome P450, family 4, subfamily f	286905	4.71	0.00000
Cyp4f14	cytochrome P450, family 4, subfamily f	56266	0.48	0.00005
Cyp4f18	cytochrome P450, family 4, subfamily f	72054	0.47	0.00014
Cyp7a1	cytochrome P450, family 7, subfamily a	25428	6.16	0.00067
Cyp7b1	cytochrome P450, family 7, subfamily b	13123	2.15	0.00169
Cyp11b3	cytochrome P450, family 11, subfamily b	353498	0.43	0.00032
Cyp26	cytochrome P450, family 26	154985	18.54	0.00005
Cyp39a1	cytochrome P450, family 39, subfamily a	56050	0.29	0.00315
Phase II metabolism
Gsta3	glutathione S-transferase, alpha 3	14859	14.47	0.00001
Gstm3	glutathione S-transferase, mu 3	81869	0.39	0.00173
Gstp1	glutathione S-transferase, pi 1	14869	3.16	0.00001
Phase III metabolism
Abcb9	ATP-binging cassette, subfamily b (MDR/TAP)	63886	0.23	0.00292
Abcc1	ATP-binging cassette, subfamily c (CFTR/MRP)	24565	2.65	0.00132
Abcc3	ATP-binging cassette, subfamily c (CFTR/MRP)	140668	21.20	0.00006
Abcc6	ATP-binging cassette, subfamily c (CFTR/MRP)	81642	0.42	0.00000
Abcc8	ATP-binging cassette, subfamily c (CFTR/MRP)	25559	0.10	0.00000

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