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Table 3 Genes involved in endothelial cells altered by comfrey treatment in liver

From: Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)

Gene symbol

Gene description

Locus link ID

Fold change

P-value

Cell death and apoptosis

*, • Angpt2

angiopoietin 2

11601

3.45

0.00121

App

amyloid beta (A4) precursor protein

54226

4.69

0.00000

Atf3

activating transcription factor 3

25389

6.22

0.00010

Bcl2

B-cell cLL/lymphoma 2

24224

2.41

0.00500

Bcl2a1

Bcl2-related protein A1

170929

3.43

0.00022

Bcl2l

Bcl2-like

12048

2.53

0.00000

Casp1

caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)

25166

2.26

0.00551

Cnp

2',3'-cyclic nucleotide 3' phosphodiesterase

1267

2.37

0.00010

• Col4a2

collagen, type IV, alpha 2

1284

2.81

0.00000

• Cxcr4

chemokine receptor (LCR1)

60628

3.22

0.00186

Dusp6

dual specificity phosphatase 6

116663

2.31

0.00036

Edn1

endothelin 1

24323

4.87

0.00033

Fgf1

fibroblast growth factor 1

25317

2.05

0.00057

*Gpr9

G protein-coupled receptor 9 (Cxcr3)

84475

2.02

0.00944

• Hgf

hepatocyte growth factor

24446

3.18

0.00065

Hmox1

heme oxygenase 1

24451

3.23

0.00064

Il2

interleukin 2

116562

0.29

0.00010

Ins1

insulin 1

24505

0.22

0.00000

Lrp5

low density lipoprotein receptor-related protein 5

16973

0.35

0.00010

Mapk9

mitogen-activated protein kinase 9

50658

0.49

0.00009

Pparg

peroxisome proliferator activated receptor, gamma

25664

0.32

0.00033

Serpinf1

serine (or cysteine) proteinase inhibitor, clade F), member 1

287526

0.49

0.00009

*Spp1

secreted phosphoprotein 1

25353

11.63

0.00003

*, • Tgfb1

transforming growth factor, beta 1

59086

2.11

0.00002

Tnfrsf6

tumor necrosis factor receptor superfamily, member 6

246097

3.40

0.00007

Tnfsf10

tumor necrosis factor (ligand) superfamily, member 10

246775

2.19

0.00366

Adhesion

Anxa1

annexin 1

25380

2.50

0.00009

Anxa5

annexin 5

25673

4.29

0.00000

Cd44

CD44 antigen

25406

2.65

0.00004

Cx3cl1

chemokine (C-X3-C motif) ligand 1

89808

2.55

0.00333

• Cxcl4

chemokine (C-X-C motif) ligand 4

56744

3.12

0.00008

Cyr61

cysteine rich protein 61

83476

4.54

0.00000

•Itga4

integrin alpha 4

16401

5.28

0.00002

•Itgav

integrin alpha V

16410

2.00

0.00113

Selplg

selectin P ligand

6404

2.26

0.00088

Cell movement

Agt

angiotensinogen

24179

0.36

0.00000

Ccl2

chemokine (C-C motif) ligand 2

24770

4.27

0.00026

Cd151

CD151 antigen

64315

2.13

0.00000

Cd9

CD9 antigen

12527

2.10

0.00127

Ceacam1

carcinoembryonic antigen-related cell adhesion molecule 1

81613

0.49

0.00138

Cxcl12

chemokine (C-X-C motif) ligand 12

24772

0.19

0.00000

Edil3

EGF-like repeats and discoidin I-like domains 3

10085

3.57

0.00015

Efnb2

ephrin B2

13642

0.49

0.00006

Fgfr1

Fibroblast growth factor receptor 1

79114

2.25

0.00002

Id1

Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation)

25261

2.89

0.00068

Lgals3

lectin, galactose binding, soluble 3

83781

2.31

0.00003

Mmp2

matrix metalloproteinase 2

17390

4.31

0.00000

Plaur

urokinase plasminogen activator receptor

50692

2.93

0.00164

Ptk2b

protein tyrosine kinase 2 beta

50646

3.85

0.00000

S100a4

S100 calcium-binding protein A4

24615

3.61

0.00001

Serpine1

serine (or cysteine) proteinase inhibitor, clade E, member 1 (plasminogen activator inhibitor type 1)

24617

30.94

0.00003

Stc1

stanniocalcin 1

81801

3.50

0.00306

TEK

TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)

7010

0.34

0.00012

Tgfb2

transforming growth factor, beta 2

81809

2.31

0.00458

Tnfrsf12a

tumor necrosis factor receptor superfamily, member 12a

302965

2.91

0.00090

  1. Genes also involved in adhesion* and cell movement• of endothelial cells.
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BMC Bioinformatics

ISSN: 1471-2105

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