Table 4 Genes involved in liver injury and abnormalities altered by comfrey-treatment
Gene symbol | Gene description | Locus link ID | Fold change | P-value |
|---|---|---|---|---|
Cell death of liver cells | ||||
Bcl2 | B-cell cLL/lymphoma 2 | 24224 | 2.41 | 0.00500 |
Bcl2l | Bcl2-like | 12048 | 2.53 | 0.00000 |
*Ccr2 | chemokine receptor CCR2 gene | 60463 | 2.47 | 0.00591 |
Cdkn1a | cyclin-dependent kinase inhibitor 1A (p21) | 114851 | 4.83 | 0.00014 |
Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 24253 | 0.46 | 0.00000 |
Egf | epidermal growth factor | 25313 | 0.36 | 0.00000 |
Hmox1 | heme oxygenase 1 | 24451 | 3.23 | 0.00064 |
Ier3 | immediate early response 3 | 294235 | 2.24 | 0.00002 |
Itgav | integrin alpha V | 16410 | 2.00 | 0.00113 |
*Krt2-8 | keratin complex 2, basic, gene 8 | 25626 | 2.82 | 0.00000 |
Nos2 | nitric oxide synthase 2, inducible | 24599 | 3.38 | 0.00491 |
*, • Tgfb1 | transforming growth factor, beta 1 | 59086 | 2.11 | 0.00002 |
Tnfrsf5 | tumor necrosis factor receptor superfamily, member 5 | 21939 | 3.58 | 0.00009 |
*, • Tnfrsf6 | Tumor necrosis factor receptor superfamily, member 6 | 246097 | 3.40 | 0.00007 |
Tnfsf10 | tumor necrosis factor (ligand) superfamily, member 10 | 246775 | 2.19 | 0.00366 |
Ugcg | UDP-glucose ceramide glycosyltransferase | 83626 | 2.08 | 0.00000 |
Growth of liver cells | ||||
Ccne1 | cyclin E1 | 898 | 7.93 | 0.00000 |
Edn1 | endothelin 1 | 24323 | 4.87 | 0.00033 |
*, • Hgf | hepatocyte growth factor | 24446 | 3.18 | 0.00065 |
Inhba | inhibin beta-A (activin A) | 29200 | 0.08 | 0.00000 |
Tgfb1 | transforming growth factor, beta 1 | 59086 | 2.11 | 0.00002 |
Timp1 | tissue inhibitor of metalloproteinase 1 | 116510 | 4.25 | 0.00000 |
Liver fibrosis | ||||
Adrb2 | adrenergic receptor, beta 2 | 24176 | 3.58 | 0.00000 |
Agt | angiotensinogen | 24179 | 0.36 | 0.00000 |
Agtr1a | angiotensin II receptor, type 1 (AT1A) | 24180 | 0.38 | 0.00000 |
Atf3 | activating transcription factor 3 | 25389 | 6.22 | 0.00010 |
Cav | caveolin | 25404 | 3.15 | 0.00006 |
Cxcl4 | chemokine (C-X-C motif) ligand 4 | 56744 | 3.12 | 0.00008 |
Cxcl12 | chemokine (C-X-C motif) ligand 12 | 24772 | 0.19 | 0.00000 |
F11 | coagulation factor XI | 109821 | 0.43 | 0.00000 |
Igf1 | insulin-like growth factor 1 | 24482 | 0.48 | 0.00000 |
Lif | leukemia inhibitory factor | 60584 | 0.41 | 0.00215 |
Serpine1 | serine (or cysteine) proteinase inhibitor, clade E member 1 (plasminogen activator inhibitor type 1) | 24617 | 30.94 | 0.00003 |
Liver morphology | ||||
Ccnd1 | cyclin D1 | 58919 | 5.65 | 0.00002 |
Ins1 | insulin 1 | 24505 | 0.22 | 0.00000 |
Junb | Jun-B oncogene | 24517 | 3.77 | 0.00001 |
Liver cancer development | ||||
Bcl2 | B-cell cLL/lymphoma 2 | 24224 | 2.41 | 0.00500 |
Ccne1 | cyclin E1 | 898 | 7.93 | 0.00000 |
Gadd45a | growth arrest and DNA-damage-inducible 45 alpha | 25112 | 2.15 | 0.00326 |
Gjb1 | gap junction membrane channel protein beta 1 | 29584 | 0.48 | 0.00003 |
Hgf | hepatocyte growth factor | 24446 | 3.18 | 0.00065 |
Ndr1 | N-myc downstream regulated 1 (Ndrg1) | 10397 | 2.26 | 0.00020 |
Timp1 | tissue inhibitor of metalloproteinase 1 | 116510 | 4.25 | 0.00000 |
Xpc | xeroderma pigmentosum, complementation group C | 7508 | 0.42 | 0.00001 |