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Table 2 Genes involved in oxidation in mouse primary hepatocytes treated with 100 μM of 3 drugs for 24 hours

From: Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor α agonists

Gene symbol Gene description Locus link ID Bezafibrate Fenofibrate WY-14,643
    fc p fc p fc p
*Abcd3 ATP-binding cassette, sub-family D (ALD), member 3 19299    1.88 0.032 1.97 0.017
Acacb acetyl-Coenzyme A carboxylase beta 100705 2.99 0.000 2.85 0.009 3.26 0.008
*Acadvl acyl-Coenzyme A dehydrogenase, very long chain 11370 1.97 0.000 2.11 0.017   
*Acox1 acyl-Coenzyme A oxidase 1, palmitoyl 11430 2.91 0.019 3.01 0.012   
Acsl1 acyl-CoA synthetase long-chain family member 1 14081 1.92 0.033 2.04 0.013 2.40 0.001
Acsl4 acyl-CoA synthetase long-chain family member 4 50790 1.75 0.005 1.91 0.012 1.66 0.019
Acsl5 acyl-CoA synthetase long-chain family member 5 433256 1.67 0.010 1.57 0.018 1.55 0.001
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 19378 2.13 0.013 2.12 0.043   
Cd36 CD36 antigen 12491 3.00 0.017 2.93 0.032   
*Cpt1a carnitine palmitoyltransferase 1a, liver 12894    1.52 0.000 1.61 0.015
*Ech1 enoyl coenzyme A hydratase 1, peroxisomal 51798 2.79 0.011 2.64 0.007 2.57 0.005
*Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase 74147 7.12 0.000 7.38 0.001 7.61 0.004
Fabp1 fatty acid binding protein 1, liver 14080 27.80 0.001 34.35 0.004 20.96 0.014
*Hadha hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit 97212 1.95 0.035 1.81 0.002 1.92 0.000
*Hadhb hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit 231086 2.24 0.020 2.18 0.004 2.24 0.007
*Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 15488 1.53 0.023 1.67 0.012   
Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 27273 10.18 0.012 8.68 0.004 19.88 0.000
Scd stearoyl-Coenzyme A desaturase 1 20249 5.50 0.004 4.51 0.023   
*Slc27a2 solute carrier family 27 (fatty acid transporter), member 2 26458 2.79 0.019 2.98 0.026   
  1. *Ten genes also involved in β-oxidation. fc, Fold change; p, P-value.
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BMC Bioinformatics

ISSN: 1471-2105

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