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Table 2 Genes involved in oxidation in mouse primary hepatocytes treated with 100 μM of 3 drugs for 24 hours

From: Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor α agonists

Gene symbol

Gene description

Locus link ID

Bezafibrate

Fenofibrate

WY-14,643

   

fc

p

fc

p

fc

p

*Abcd3

ATP-binding cassette, sub-family D (ALD), member 3

19299

  

1.88

0.032

1.97

0.017

Acacb

acetyl-Coenzyme A carboxylase beta

100705

2.99

0.000

2.85

0.009

3.26

0.008

*Acadvl

acyl-Coenzyme A dehydrogenase, very long chain

11370

1.97

0.000

2.11

0.017

  

*Acox1

acyl-Coenzyme A oxidase 1, palmitoyl

11430

2.91

0.019

3.01

0.012

  

Acsl1

acyl-CoA synthetase long-chain family member 1

14081

1.92

0.033

2.04

0.013

2.40

0.001

Acsl4

acyl-CoA synthetase long-chain family member 4

50790

1.75

0.005

1.91

0.012

1.66

0.019

Acsl5

acyl-CoA synthetase long-chain family member 5

433256

1.67

0.010

1.57

0.018

1.55

0.001

Aldh1a2

aldehyde dehydrogenase family 1, subfamily A2

19378

2.13

0.013

2.12

0.043

  

Cd36

CD36 antigen

12491

3.00

0.017

2.93

0.032

  

*Cpt1a

carnitine palmitoyltransferase 1a, liver

12894

  

1.52

0.000

1.61

0.015

*Ech1

enoyl coenzyme A hydratase 1, peroxisomal

51798

2.79

0.011

2.64

0.007

2.57

0.005

*Ehhadh

enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase

74147

7.12

0.000

7.38

0.001

7.61

0.004

Fabp1

fatty acid binding protein 1, liver

14080

27.80

0.001

34.35

0.004

20.96

0.014

*Hadha

hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit

97212

1.95

0.035

1.81

0.002

1.92

0.000

*Hadhb

hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit

231086

2.24

0.020

2.18

0.004

2.24

0.007

*Hsd17b4

hydroxysteroid (17-beta) dehydrogenase 4

15488

1.53

0.023

1.67

0.012

  

Pdk4

pyruvate dehydrogenase kinase, isoenzyme 4

27273

10.18

0.012

8.68

0.004

19.88

0.000

Scd

stearoyl-Coenzyme A desaturase 1

20249

5.50

0.004

4.51

0.023

  

*Slc27a2

solute carrier family 27 (fatty acid transporter), member 2

26458

2.79

0.019

2.98

0.026

  
  1. *Ten genes also involved in β-oxidation. fc, Fold change; p, P-value.
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BMC Bioinformatics

ISSN: 1471-2105

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